Chemical constituents of glucoside fraction from Liuwei Dihuang Gantang / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study chemical constituents of glucoside fraction from Liuwei Dihuang Gantang and clarify its substance foundation of active constituents.</p><p><b>METHOD</b>Glucoside fraction was prepared by macroporous resin chromatography. Constituents were separated by silica gel and reverse phase silica gel column chromatography, and their structures were identified by MS and NMR.</p><p><b>RESULT</b>Eleven compounds were separated and identified as 7-dehydrologanin (1), 7alpha-O-methylmorroniside (2), 7beta-O-methylmorroniside (3), 7alpha-O-ethylmorroniside (4), 7beta-O-ethylmorroniside (5), morroniside (6), sweroside (7), loganin (8), paeoniflorin (9), paeonolide (10) and loganic acid (11).</p><p><b>CONCLUSION</b>All of those compounds were separated from Liuwei Dihuang Gantang for the first time.</p>