Acute leukemia associated with Down syndrome: clinical analysis of 21 cases / 南方医科大学学报
Journal of Southern Medical University
; (12): 433-436, 2016.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-264025
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To summarize the clinical characteristics, laboratory findings and prognosis of patients with Down syndrome-related acute leukemia (DS-AL).</p><p><b>METHODS</b>The clinical data, laboratory findings, chemotherapy and prognosis of 21 children with DS-AL were analyzed.</p><p><b>RESULTS</b>Most of the children had disease onset of leukemia at 1 to 5 years of age (85.7%), and acute myeloid leukemia accounted for 57.1% of these cases; 61.9% of the patients had increased lactate dehydrogenase level by 2 folds or more. Of the 13 cases undergoing echocardiaography, 10 (67.9%) showed abnormal findings, and complex congenital heart disease was common (38.5%). Six of the children received chemotherapy and complete remission was achieved in 4 cases; 2 patients died of infection, and the treatment-related mortality was 33.3%. The 2 patients receiving reduced intensive chemotherapy have so far had event-free survival for 21 and 43 months.</p><p><b>CONCLUSION</b>Acute myeloid leukemia is the most common subtype of DS-AL. Patients with DS-AL are sensitive to chemotherapy and the prognosis was favorable with reduced intensive chemotherapy.</p>
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
/
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
/
ODS3 - Meta 3.2 Reduzir as mortes de recém nascidos e crianças com menos de 5 anos
Problema de saúde:
Meta 3.2: Reduzir as mortes de recém nascidos e crianças com menos de 5 anos
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Anomalias Congênitas e Cromossômicas
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Leucemia
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Cuidados de Saúde Neonatal
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Doenças Não Transmissíveis
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
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Indução de Remissão
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Leucemia Mieloide Aguda
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Protocolos de Quimioterapia Combinada Antineoplásica
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Síndrome de Down
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Intervalo Livre de Doença
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Tratamento Farmacológico
Tipo de estudo:
Estudo prognóstico
Limite:
Criança, pré-escolar
/
Humanos
/
Lactente
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2016
Tipo de documento:
Artigo