Research progress on B lymphocyte-induced maturation protein 1 and its relationship with the development of lymphoma / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 1623-1626, 2013.
Article
em Zh
| WPRIM
| ID: wpr-264964
Biblioteca responsável:
WPRO
ABSTRACT
Many studies show that as a transcription factor, B lymphocyte-induced maturation protein 1 (Blimp 1) is the master regulator of plasma-cell differentiation. The abnormality of Blimp 1 plays an important part in the genesis and development of lymphoma. This review introduces and summarizes Blimp 1's protein structure and functions, its role in B cell differentiation, its main target genes and the mechanism of its transcriptional repressor activity. Besides, the relationship between Blimp 1 gene mutation or Blimp 1 protein expression reduction and the development of DLBCL is preliminary summaried.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Proteínas Repressoras
/
Fatores de Transcrição
/
Linfócitos B
/
Diferenciação Celular
/
Linfoma Difuso de Grandes Células B
/
Antígeno de Maturação de Linfócitos B
/
Fator 1 de Ligação ao Domínio I Regulador Positivo
/
Genética
/
Metabolismo
Limite:
Humans
Idioma:
Zh
Revista:
Journal of Experimental Hematology
Ano de publicação:
2013
Tipo de documento:
Article