Unraveling the chromosome higher-order structures in the transcriptional regulation of hematopoiesis by chromosome conformation capture / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 1369-1372, 2013.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-265011
Biblioteca responsável:
WPRO
ABSTRACT
Emerging evidence has demonstrated that genomes are organized into higher-order structures in vivo and long range interactions between genomic regions largely contribute to the regulation of gene expression. Hematopoiesis, orchestrated by the precise spatial regulation and organization of hematopoietic transcription factors, serves as a good model for exploring these issues. The chromosome conformation capture (3C) methodology and its high throughput based technology provide an innovative solution for analyzing the regulation of functional elements through inter-chromosomal and intra-chromosomal interactions, and contacts of functional components in nuclei, thus leading to a more comprehensive understanding of human genome and gene expression. This review focuses on the recent progress of 3C and its derivatives, and their applications in unraveling the mechanisms of transcriptional regulation in hematopoiesis.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Regulação da Expressão Gênica
/
Técnicas Genéticas
/
Cromossomos
/
Genômica
/
Genética
/
Hematopoese
/
Conformação de Ácido Nucleico
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Experimental Hematology
Ano de publicação:
2013
Tipo de documento:
Artigo