Anti-emetic effect of ethanol extract from "Wuzhuyu broth" / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 862-866, 2002.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-266844
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the anti-emetic effect of ethanol extract from "WuZhuYu broth" and its mechanism.</p><p><b>METHOD</b>Three experiments were carried out test which extract has anti-emetic activity, such as CuSO4-induced pigeon's emetic response, gastric emptying in mice and ACh-induced or 5-HT-induced contraction in vitro gastric muscle in rats. Meanwhile, effect of anti-emetic extract on concentration-response curve to ACh, 5-HT, histamine was investigated.</p><p><b>RESULT</b>50% ethanol extract and 70% ethanol extract were identified as having significantly stronger anti-emetic activities with little side effect, which showed the significant effect on concentration-response curve to ACh, 5-HT, histamine.</p><p><b>CONCLUSION</b>50% ethanol extract and 70% ethanol extract contain more anti-emetic fractions, more anti-emetic fractions can be gained at the concentrations of 50% and 70% ethanol; the mechanism of anti-emetic effect is related to its antagonism to the receptors of ACh, 5-HT, histamine.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Columbidae
/
Plantas Medicinais
/
Vômito
/
Medicamentos de Ervas Chinesas
/
Química
/
Ratos Sprague-Dawley
/
Evodia
/
Usos Terapêuticos
/
Combinação de Medicamentos
/
Tratamento Farmacológico
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2002
Tipo de documento:
Artigo