Bioinformatic analysis of genes related to temporal epilepsy / 南方医科大学学报
Journal of Southern Medical University
; (12): 180-183, 2011.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-267643
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the genes associated with temporal epilepsy and explore the molecular mechanism of epilepsy.</p><p><b>METHODS</b>The microarray data of temporal epilepsy were downloaded from the Gene Expression Omnibus (GEO) database and analyzed by bioinformatics methods using String, KEGG and Panther databases.</p><p><b>RESULTS</b>Of all the 71 differentially expressed genes, 51 were found to encode proteins with interactions; the main biological pathways involved included neuroactive ligand-receptor interactions, MAPK signaling pathway, and calcium signaling pathway etc.</p><p><b>CONCLUSION</b>The pathogenesis of epilepsy involves multiple genes, and investigations of these genes may provide valuable insights into the mechanism of epilepsy.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Expressão Gênica
/
Biologia Computacional
/
Análise de Sequência com Séries de Oligonucleotídeos
/
Sistema de Sinalização das MAP Quinases
/
Perfilação da Expressão Gênica
/
Epilepsia do Lobo Temporal
/
Genética
/
Métodos
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2011
Tipo de documento:
Artigo