Expression of integrin-linked kinase in prostate cancer and its significance / 中华男科学杂志
National Journal of Andrology
; (12): 34-37, 2005.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-267762
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of integrin-linked kinase (ILK) in primary prostate cancer and its clinical significance.</p><p><b>METHODS</b>The expression of ILK was analysed in 50 prostate cancer and 16 benign prostatic hyperplasia samples by immunohistochemical staining.</p><p><b>RESULTS</b>The positive percentage of ILK was 46.0% (23/50) in primary prostate cancer. The higher the grade and the clinical stage of the tumor, the lower the expression of ILK. The positive percentages of ILK were 9.1% (1/11) in the well differentiated type, 56.4% (22/39) in the moderately and poorly differentiated type (chi2 = 12.28, P < 0.01), 24.0% (6/25) in the well and moderately differentiated type, 68.0% (17/25) in the poorly differentiated type (chi2 = 9.74, P < 0.01), 22.6% (7/31) at the A + B stage and 84.0% (16/19) at the C + D stage (chi2 = 11.8, P < 0.01). But in benign prostatic hyperplasia, it was only 6.2% (1/16), significantly lower than in primary prostate cancer (46.0%) (chi2 = 8.27, P < 0.01).</p><p><b>CONCLUSION</b>The abnormal expression of ILK plays an important role in the development of primary prostate cancer, and the detection of ILK may be useful for the judgement of tumor development and prognosis.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Prognóstico
/
Neoplasias da Próstata
/
Imuno-Histoquímica
/
Proteínas Serina-Treonina Quinases
/
Metabolismo
/
Estadiamento de Neoplasias
Tipo de estudo:
Estudo prognóstico
Limite:
Idoso
/
Idoso, 80 anos ou mais
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
National Journal of Andrology
Ano de publicação:
2005
Tipo de documento:
Artigo