Recent advances in the study of synthesis and activity of vancomycin derivatives / 药学学报
Acta Pharmaceutica Sinica
; (12): 463-469, 2007.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-268616
Biblioteca responsável:
WPRO
ABSTRACT
Vancomycin was enlisted as a drug of the last resort for the treatment of resistant gram-positive bacterial infections. However, the emergence of vancomycin-resistant bacteria has created an urgent need for new active analogues of vancomycin. Summing up the last ten years work of this field, the review introduced the antibiotic mechanism of vancomycin and summarized the vancomycin derivatives based on the modifications of vancomycin, dimmer of vancomycin and the vancomycin mimetics. The connection of modified location and function with antibacterial activity was also discussed.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Vancomicina
/
Estrutura Molecular
/
Testes de Sensibilidade Microbiana
/
Química
/
Resistência a Vancomicina
/
Antibacterianos
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2007
Tipo de documento:
Artigo