Pathologic changes caused by highly pathogenic H5N1 avian influenza virus: postmortem study of a case / 中华病理学杂志
Chinese Journal of Pathology
; (12): 545-548, 2006.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-268905
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To report the postmortem findings of a case of highly pathogenic H5N1 avian influenza virus occurring in human beings.</p><p><b>METHODS</b>Postmortem examination was carried out in a deceased caused by highly pathogenic H5N1 avian influenza virus. Detailed light microscopy of major organs, including heart, lungs, liver, spleen, kidneys and brain, was performed. The lung tissue was further investigated by histochemistry, immunohistochemistry and electron microscopy.</p><p><b>RESULTS</b>Major histopathologic changes in lungs secondary to highly pathogenic H5N1 avian influenza virus included diffuse alveolar damage, hyaline membrane formation and focal hemorrhage. Some of the alveolar spaces contained lightly eosinophilic liquid, lymphocytes, macrophages, plasma cells and small number of neutrophils. Congested capillaries were commonly seen in the alveolar septa which were focally rimmed by hyaline membrane. Immunohistochemical study showed that the lymphocytes were mainly of T lineage and macrophages were also demonstrated.</p><p><b>CONCLUSIONS</b>Highly pathogenic H5N1 avian influenza virus causes pathologic changes mostly in lungs, including diffuse alveolar damage and acute exudative changes (involving mainly T lymphocytes and macrophages). The resulting parenchymal destruction, consolidation, pulmonary edema and hemorrhage eventually lead to respiratory distress and death.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Autopsia
/
Virologia
/
Imuno-Histoquímica
/
Microscopia Eletrônica
/
Antígenos Comuns de Leucócito
/
Complexo CD3
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Evolução Fatal
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Influenza Humana
/
Virus da Influenza A Subtipo H5N1
Limite:
Adulto
/
Feminino
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Pathology
Ano de publicação:
2006
Tipo de documento:
Artigo