Correlations between preS1-antigen, HBV-DNA and HBV serum markers in patients with chronic hepatitis B / 南方医科大学学报
Journal of Southern Medical University
; (12): 1184-1186, 2008.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-270180
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the correlations between preS1 antigen, HBV-DNA and hepatitis B virus (HBV) serum markers in patients with chronic hepatitis B.</p><p><b>METHODS</b>The HBV markers, preS1 antigen and HBV-DNA were determined using enzyme- linked immunosorbent assay and quantitative PCR in 1158 patients with chronic hepatitis B.</p><p><b>RESULTS</b>In these patients, the HBV-DNA positivity rate was 68.9%, significantly higher than preS1 antigen positivity (54.8%, chi2=53.24, P<0.005). The positivity rates of both HBV-DNA and PreS1-antigen were significantly higher in HBeAg-positive patients than in HBeAg-negative patients (P<0.005). The coincident rates of preS1-antigen and HBeAg with HBV-DNA were 56.9% and 63.3%, respectively. PreS1 antigen had higher sensitivity but lower specificity than HBeAg. The detection rates of preS1 antigen and HBeAg increased with the level of HBV-DNA, and preS1 antigen positivity was higher than that of HBeAg in patients with low HBV-DNA levels.</p><p><b>CONCLUSION</b>Detection of HBV serum markers along with preS1 antigen and HBV-DNA may help assess the status of viral replication and therapeutic efficacy in patients with chronic hepatitis B. PreS1 antigen may serve as an auxiliary indicator in HBeAg-negative cases or when HBV-DNA detection is impossible.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Precursores de Proteínas
/
Virologia
/
Replicação Viral
/
Sangue
/
DNA Viral
/
Vírus da Hepatite B
/
Hepatite B Crônica
/
Alergia e Imunologia
/
Genética
/
Antígenos E da Hepatite B
Limite:
Adolescente
/
Adulto
/
Idoso
/
Idoso, 80 anos ou mais
/
Criança
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2008
Tipo de documento:
Artigo