Anemia in patients on combined androgen block therapy for prostate cancer / 亚洲男科学杂志(英文版)

ABSTRACT

<p><b>AIM</b>To study the effect of combined androgen block therapy on hemoglobin and hematocrit values in patients with prostate cancer.</p><p><b>METHODS</b>One hundred and thirty-six patients with adenocarcinoma of prostate were treated with combined androgen block (orchiectomy and flutamide 250 mg, tid). Complete blood counts were determined before and after 1, 2, 3, 6, 9 and 12 months of therapy.</p><p><b>RESULTS</b>The hemoglobin and hematocrit levels declined significantly in all patients and at all the time points after treatment (P<0.05).</p><p><b>CONCLUSION</b>Prostate cancer patients treated with combined androgen block would develop obvious anemia. Recombinant human erythropoietin can be used to treat patients with severe anemia.</p>