Prognostic value of expression of FASE, HER-2/neu, bcl-2 and p53 in stage I non-small cell lung cancer / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 369-372, 2004.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-271011
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the prognostic value of expression of fatty acid synthase (FASE), HER-2/neu, bcl-2 and p53 in stage I non-small cell lung cancer (NSCLC).</p><p><b>METHODS</b>Expression of FASE, HER-2/neu, bcl-2 and p53 protein was detected by immunohistochemical staining in 84 patients with stage I NSCLC who underwent surgery. Multiple clinical parameters and survival were analyzed.</p><p><b>RESULTS</b>The expression of FASE, HER-2/neu, bcl-2 and p53 was 29.8%, 40.5%, 33.3% and 39.3%, respectively. The local recurrence and bone-metastasis rate were higher in FASE positive patients than in negative patients (28.0% vs 10.2%, P = 0.05; 61.5% vs 23.9%, P = 0.017, respectively). The 5-year survival rate was lower in HER-2/neu and FASE positive patients than in negative patients (37.7% vs 67.7%, P = 0.0083; 35.1% vs 66.1%, P = 0.0079, respectively), which showed that HER-2/neu and FASE expression were associated with significantly poor survival. Patients whose tumors were both HER-2/neu and FASE negative had better outcome, with a 5-year survival rate of 78.2%, compared with 36.3% in those whose tumors were positive for either one (P = 0.002). However, bcl-2 and p53 were not independent prognostic factors for survival.</p><p><b>CONCLUSION</b>HER-2/neu and FASE are independent prognostic factor in stage I non-small cell lung cancer patients who expressed one or both markers.</p>
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Disponível
Contexto em Saúde:
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Outras Neoplasias Malignas
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Outras Doenças Respiratórias
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Neoplasias do Pulmão, Traqueia e Brônquios
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
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Cirurgia Geral
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Neoplasias Ósseas
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Fumar
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Biomarcadores Tumorais
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Taxa de Sobrevida
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Seguimentos
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Mortalidade
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Proteína Supressora de Tumor p53
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Carcinoma Pulmonar de Células não Pequenas
Tipo de estudo:
Estudo observacional
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Estudo prognóstico
Limite:
Adulto
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Idoso
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Feminino
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Humanos
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Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Oncology
Ano de publicação:
2004
Tipo de documento:
Artigo