Vascular effect of extract from mulberry leaves and underlying mechanism / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 48-53, 2007.
Article
em Zh
| WPRIM
| ID: wpr-271577
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the vascular activity of extract from mulberry leaves (EML) on rat thoracic aorta and the underlying mechanism.</p><p><b>METHODS</b>Isolated thoracic rings of Sprague-Dawley rats were mounted on the organ bath and the tension of the vessel was recorded.</p><p><b>RESULT</b>(1) EML produced a concentration-dependent vasorelaxation of aorta preconstricted by high K(+) (60 mmol/L) or 10(-6) mol/L phenylephrine (PE) in endothelium-intact and endothelium-denuded arteries. (2) EML at EC(50) concentration reduced the calcium dose-response curve. (3) After incubation of aorta with verapamil, EML induced vasocontraction of aorta preconstricted by PE, which was abolished by ruthenium red.</p><p><b>CONCLUSION</b>The vascular effect of EML is biphasic, the vasorelaxation is greater than the vasocontraction. The vasorelaxation induced by EML may be mediated by inhibition of voltage-and receptor-dependent calcium channels in vascular smooth muscle cells, while the vasocontraction is via activation of ryanodine receptor in endoplasmic reticulum.</p>
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Base de dados:
WPRIM
Assunto principal:
Aorta Torácica
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Farmacologia
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Fisiologia
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Potássio
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Vasoconstrição
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Vasodilatação
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Técnicas In Vitro
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Extratos Vegetais
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Química
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Ratos Sprague-Dawley
Limite:
Animals
Idioma:
Zh
Revista:
Journal of Zhejiang University. Medical sciences
Ano de publicação:
2007
Tipo de documento:
Article