Effects of imatinib mesylate on the levels of endocrine hormones / 中华血液学杂志
Chinese Journal of Hematology
; (12): 762-766, 2013.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-272118
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To measure the levels of hormones in chronic myelogenous leukemia (CML) patients receiving imatinib mesylate (IM) and evaluate the effects of IM on endocrine system.</p><p><b>METHODS</b>69 patients with CML while taking IM were enrolled and a total of 86 peripheral blood samples were detected. The levels of total triiodothyronine (TT3), total tetraiodothyronine (TT4), thyroid stimulating hormone (TSH), testosterone, progesterone, estradiol (E2), plasma total cortisol (PTC) at 800-1000 am measured. Concentration of hormones in different groups were measured to evaluate the effects of IM on endocrine system and relationships with its administration duration, plasma concentration and clinical symptoms.</p><p><b>RESULTS</b>(1) Of the 7 types of hormones, an elevation of TSH level was found in 14 patients (20.3%), a decrease of TT3 and testosterone in 8 patients (11.6%) and 8 males (18.6%), respectively. (2) A significant decline of TT3 and testosterone was observed in all patients divided by different administration duration. Negative correlation was seen between TT3 level and duration of administration (r=-0.273, P=0.010), which was also found for testosterone (r=-0.302, P=0.025). (3) There was no correlation between serum levels of the seven hormones and concentration of IM.</p><p><b>CONCLUSION</b>IM affect the levels of thyroid and sex hormones in some patients with clinical manifestations a decrease of TT3, testosterone and testosterone, an increase of TSH, which have relationship with the duration of administration.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Piperazinas
/
Pirimidinas
/
Tri-Iodotironina
/
Benzamidas
/
Sangue
/
Tireotropina
/
Leucemia Mielogênica Crônica BCR-ABL Positiva
/
Usos Terapêuticos
/
Tratamento Farmacológico
/
Mesilato de Imatinib
Limite:
Adolescente
/
Adulto
/
Idoso
/
Idoso, 80 anos ou mais
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Hematology
Ano de publicação:
2013
Tipo de documento:
Artigo