The expressions of inflammatory factors and tissue inhibitor of matrix metalloproteinase-2 in human chronic periodontitis with type 2 diabetes mellitus
Journal of Periodontal & Implant Science
; : 33-38, 2010.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-27385
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
The purpose of this study was to observe and quantify the expression of interleukin-4 (IL-4), interferon-gamma (IFN-gamma), and tissue inhibitor of matrix metalloproteinase-2 (TIMP-2) in the gingival tissue of patients with type 2 diabetes mellitus (DM) and healthy adults with chronic periodontitis.METHODS:
Twelve patients with type 2 DM and chronic periodontitis (Group 3), twelve patients with chronic periodontitis (Group 2), and twelve healthy individuals (Group 1) were included in the study. Clinical criteria of gingival (sulcus bleeding index value, probing depths) and radiographic evidences of bone resorption were divided into three groups. The concentrations of cytokines were determined by a western blot analysis and compared using one-way ANOVA followed by Tukey's test.RESULTS:
The expression levels of IFN-gamma and TIMP-2 showed an increasing tendency in Groups 2 and 3 when compared to Group 1. On the other hand, the expression of IL-4 was highest in Group 1.CONCLUSIONS:
The findings suggest that IFN-gamma and TIMP-2 may be involved in the periodontal inflammation associated with type 2 DM. IL-4 may be involved in the retrogression of the periodontal inflammation associated with type 2 DM.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Reabsorção Óssea
/
Western Blotting
/
Citocinas
/
Interleucina-4
/
Interferon gama
/
Inibidores Teciduais de Metaloproteinases
/
Inibidor Tecidual de Metaloproteinase-2
/
Metaloproteinase 2 da Matriz
/
Diabetes Mellitus Tipo 2
/
Periodontite Crônica
Limite:
Adulto
/
Humanos
Idioma:
Inglês
Revista:
Journal of Periodontal & Implant Science
Ano de publicação:
2010
Tipo de documento:
Artigo