Spontaneous remission of acromegaly or gigantism due to subclinical apoplexy of pituitary growth hormone adenoma / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 3820-3823, 2011.
Article
em En
| WPRIM
| ID: wpr-273968
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>BACKGROUND</b>Subclinical apoplexy of pituitary functional adenoma can cause spontaneous remission of hormone hypersecretion. The typical presence of pituitary growth hormone (GH) adenoma is gigantism and/or acromegaly. We investigated the clinical characteristics of patients with spontaneous partial remission of acromegaly or gigantism due to subclinical apoplexy of GH adenoma.</p><p><b>METHODS</b>Six patients with spontaneous remission of acromegaly or gigantism were enrolled. The clinical characteristics, endocrinological evaluation and imageological characteristics were retrospectively analyzed.</p><p><b>RESULTS</b>In these cases, the initial clinical presences were diabetes mellitus or hypogonadism. No abrupt headache, vomiting, visual function impairment, or conscious disturbance had ever been complained of. The base levels of GH and insulin growth factor-1 (IGF-1) were normal or higher, but nadir GH levels were all still > 1 µg/L in 75 g oral glucose tolerance test. Magnetic resonance imaging detected enlarged sella, partial empty sella and compressed pituitary. The transsphenoidal surgery was performed in 2 cases, and the other patients were conservatively managed. All the patients were in clinical remission.</p><p><b>CONCLUSIONS</b>When the clinical presences, endocrine evaluation, biochemical examination and imageology indicate spontaneous remission of GH hypersecretion in patients with gigantism or acromegaly, the diagnosis of subclinical apoplexy of pituitary GH adenoma should be presumed. To these patients, conservative therapy may be appropriate.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Neoplasias Hipofisárias
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Acromegalia
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Imuno-Histoquímica
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Imageamento por Ressonância Magnética
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Diagnóstico
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Adenoma Hipofisário Secretor de Hormônio do Crescimento
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Gigantismo
Tipo de estudo:
Diagnostic_studies
Limite:
Adolescent
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Adult
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Aged
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Chinese Medical Journal
Ano de publicação:
2011
Tipo de documento:
Article