Experimental studies on the anti-thrombosis effect of 3,4-oxo-isopropylidene-shikimic acid / 药学学报
Acta Pharmaceutica Sinica
; (12): 245-248, 2002.
Article
em Zh
| WPRIM
| ID: wpr-274834
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>AIM</b>To study the effect of 3,4-oxo-isopropylidene-shikimic acid (ISA) against arteriovenous shunt and middle cerebral artery thrombosis (MCAT) in rats.</p><p><b>METHODS</b>Arteriovenous shunt model was adopted to measure thrombus weight; The neurologic deficit (ND) and the infarct size (IS) of the middle cerebral thrombosis (MCAT) model induced by FeCl3 were observed; The effect of ISA on platelet aggregation rate of rat and rabbit by giving ISA in vivo and in vitro was studied.</p><p><b>RESULTS</b>ISA 25, 50, 100 and 200 mg.kg-1 ig was shown to reduced the weight of thrombus in arteriovenous shunt model; ISA 50, 100 and 200 mg.kg-1 ig for 2 times in 24 hours, attenuated the ND of rats subjected to MCAT; ISA 100 and 200 mg.kg-1 reduced IS of rats after MCAT by 27.8% and 31.6%, respectively; ISA 50, 100 and 200 mg.kg-1 ig inhibited platelet aggregation of normal rats; ISA 10(-3)-10(-5) mol.L-1, inhibited rabbit platelet aggregation in vitro.</p><p><b>CONCLUSION</b>ISA inhibited thrombosis by anti-platelet-aggregation.</p>
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Base de dados:
WPRIM
Assunto principal:
Patologia
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Farmacologia
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Ácido Chiquímico
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Sangue
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Encéfalo
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Distribuição Aleatória
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Química
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Agregação Plaquetária
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Ratos Wistar
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Infarto da Artéria Cerebral Média
Limite:
Animals
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2002
Tipo de documento:
Article