Expression of cyclooxygenase-2 in bone marrow cells of chronic leukemia and its significance / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 923-926, 2007.
Article
em Zh
| WPRIM
| ID: wpr-276791
Biblioteca responsável:
WPRO
ABSTRACT
The study was aimed to investigate the expression of COX-2 in bone marrow cells of chronic leukemia patients and its potential pathogenetic implications. Western blot was applied for detecting COX-2 expression levels in bone marrow cells of 67 chronic leukemia patients and beta-actin expression levels. Bone marrow aspirations from 14 healthy donors were used as negative controls. The results showed that the positive rates of COX-2 in chronic-phase group of chronic myeloid leukemia (CML-CP) and in group of chronic lymphocytic leukemia (CLL) were 76.32% (29/38) and 75.86% (22/29) respectively. Both CML-CP and CLL group showed a higher expression than control group (p = 0.0000, p = 0.0000 respectively). The expression of LDH in Cox-2 positive group was higher than that in Cox-2 negative group, and the difference between the two groups was statistically significant (p < 0.001). It is concluded that the expression of COX-2 protein can be detected in bone marrow cells of CML-CP and CLL and the expression level of LDH were higher in cells of CML-CP and CLL. The expression of COX-2 may be correlated with prognosis of CML-CP and CLL.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Células da Medula Óssea
/
Leucemia Linfocítica Crônica de Células B
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Leucemia Mielogênica Crônica BCR-ABL Positiva
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Expressão Gênica
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Ciclo-Oxigenase 2
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L-Lactato Desidrogenase
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Metabolismo
Limite:
Adult
/
Aged
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Humans
Idioma:
Zh
Revista:
Journal of Experimental Hematology
Ano de publicação:
2007
Tipo de documento:
Article