Prognostic evaluation of comorbidities in patients with myelodysplastic syndrome / 中华血液学杂志
Chinese Journal of Hematology
; (12): 196-201, 2015.
Article
em Zh
| WPRIM
| ID: wpr-278878
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To discuss the impact of comorbidities on the outcomes of patients with MDS.</p><p><b>METHODS</b>The clinical characteristics of 676 MDS patients with detailed comorbidities evaluations was analyzed retrospectively.</p><p><b>RESULTS</b>There were 395/676 cases (58.4%) with comorbidities (group 1), 281/676 cases (41.6%) without (group 2). Significant differences were seen in the distribution of age (≥ 60 y), bone marrow blasts, abnormal karyotype, WHO 2008 subtypes and IPSS-R risk cohorts (P<0.05) between the two groups. While gender, HGB concentrations, WBC levels, platelet levels and serum ferritin were not significantly different (P>0.05). Independent prognostic significance of comorbidities was seen in both uni-variate and multi-variate analyses (P<0.001). According to MDS-specific comorbidity index (MDS-CI), the median survival were 32(1-153) months, 19(2-85) months and 13(1-37) months in the low-risk, intermediate-risk and high-risk cohorts respectively, while 96(1-166) months in cohorts without any comorbidities, of which significant differences were seen (P<0.001). The MDS-CI allowed further stratification in the IPSS-R low-risk, intermediate-risk and high-risk cohorts (P<0.001).</p><p><b>CONCLUSION</b>Comorbidities provides prognostic stratification independently of IPSS-R for MDS patients.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Prognóstico
/
Plaquetas
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Síndromes Mielodisplásicas
/
Comorbidade
/
Risco
/
Estudos Retrospectivos
/
Cariótipo Anormal
/
Leucócitos
Tipo de estudo:
Etiology_studies
/
Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
Zh
Revista:
Chinese Journal of Hematology
Ano de publicação:
2015
Tipo de documento:
Article