Experimental study on treatment of minimal change nephropathy with Lespedeza michx / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the therapeutic effect of Lespedeza Michx in experimental rat model of minimal change nephropathy (MCN).</p><p><b>METHOD</b>The rat MCN model was reproduced by tail-intravenous injection of Adriamycin. The treatment effect of Lespedeza Michx was determined by the detection of urine protein collection for 24 hours, malondialdehyde (MDA), superoxide dismutase (SOD), ATCO, IL-8, TNF-alpha in serum, and renal histopathological changes were observed by microscope.</p><p><b>RESULT</b>Lespedeza Michx could decrease the contents of urine proteinuria, MDA, IL-8, and TNF-alpha in serum, increase SOD level and improved the pathological change of glomeruli.</p><p><b>CONCLUSION</b>Lespedeza Michx was effective on MCN.</p>