Different mechanisms mediated the potentiation uterine smooth muscle caused by Polygala tenuifolia decoction progesterone in virginal rats / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To research the effects of Polygala tenuifolia decoction on myoelectric activity of uterine smooth muscle and contractile activity of uterine smooth muscle strips of virginal rats.</p><p><b>METHOD</b>To record the effects of P. tenuifolia decoction on myoelectric activity of uterine smooth muscle and contractile activity of uterine smooth muscle strips of virginal rats with biolap 410 biological system. Five blocking agents were used to study their mechanisms respectively.</p><p><b>RESULT</b>Different dosages of water extract of P. tenuifolia (0.02, 0.04, 0.08 g x kg(-1)), could significantly potentiate uterine myoelectric activity and contractile activity of virginal rats.</p><p><b>CONCLUSION</b>The effect of P. tenuifolia on myoelectric activity of uterine smooth muscle and contractile activity of uterine smooth muscle strips in rats may be mainly associated with H1 receptor, L-voltage-dependant calcium channels or prostaglandin synthese, its nothing to M receptor.</p>