The sinus node itself also plays a role in heart rate slowing down during postnatal development / 生理学报
Acta Physiologica Sinica
; (6): 282-286, 2002.
Article
em Zh
| WPRIM
| ID: wpr-279297
Biblioteca responsável:
WPRO
ABSTRACT
The slowing down mechanism of heart rate during growth of the body after birth was studied in isolated rabbit heart and sinus node (SN) preparation with Langendorff perfusion method, conventional microelectrode recording and perforated patch for recording pacemaker current I(f). The radioimmunoassay was also used to measure the concentration of cAMP within SN cells. The results indicate that without the influence of nervous and humoral factors, the spontaneous heart rate would also become slower as the rabbit grew older, which is due to the decrease of spontaneous depolarized rate of phase 4 in SN cells. The negative directed shift of the threshold potential of I(f) and the decrease in cAMP concentration within SN cells may be responsible for the phenomenon. The results obtained suggest that besides the nervous and humoral factors which influence the heart rate, the changes in automaticity of SN cell itself may take part in the slowing down process as the body grows up.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Perfusão
/
Fisiologia
/
Nó Sinoatrial
/
Técnicas In Vitro
/
AMP Cíclico
/
Frequência Cardíaca
/
Microeletrodos
Limite:
Animals
Idioma:
Zh
Revista:
Acta Physiologica Sinica
Ano de publicação:
2002
Tipo de documento:
Article