Study on excretion of stilbene glycoside (THSG) and its beta-cyclodextrin inclusion / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 2620-2623, 2010.
Article
em Zh
| WPRIM
| ID: wpr-279387
Biblioteca responsável:
WPRO
ABSTRACT
The excretion characteristics of stilbene glycoside (THSG) and its beta-cyclodextrin inclusion in bile, urine and feces after oral administration to rats were studied. Bile for 24 h, urine and feces for 72 h were collected. The content of THSG was determined by HPLC-UV. The established HPLC-UV method was available for the analysis of THSG in excreta and corresponded to the requirement of biological sample analysis. After given THSG and its beta-cyclodextrin inclusion, the amount of prototype THSG in feces were 3.27% and 0.61%, meanwhile THSG in bile were 0.20% and 0.18%, respectively. Only a little THSG was found in urine. The result showed that beta-cyclodextrin inclusion reduced the fecal excretion of THSG. However, the characteristic of urinary and biliary excretion wasn't changed.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Fisiologia
/
Estilbenos
/
Bile
/
Transporte Biológico
/
Corpos de Inclusão
/
Química
/
Administração Oral
/
Cromatografia Líquida de Alta Pressão
/
Ratos Sprague-Dawley
/
Secreções Corporais
Limite:
Animals
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2010
Tipo de documento:
Article