Efficacy of volume-targeted ventilation for the treatment of neonatal respiratory distress syndrome / 中国当代儿科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the efficacy of volume-targeted ventilation (VTV) for the treatment of neonatal respiratory distress syndrome (NRDS).</p><p><b>METHODS</b>Fifty-two neonates with NRDS between August 2013 and August 2015 were randomly divided into two groups VTV and pressure-controlled ventilation (PCV) (n=26 each ). A/C+Vc+ ventilation model was applied in the VTV group, and A/C+PCV ventilation model was applied in the PCV group. Arterial blood gas analysis was performed at 6, 24, and 48 hours after ventilation. The following parameters were observed time of invasive ventilation, duration of oxygen therapy, mortality, and the incidence rates of hypocapnia, pneumothorax, ventilator-associated pneumonia (VAP), grade III-IV periventricular-intraventricular hemorrhage (PVH-IVH), periventricular leukomalacia (PVL), bronchopulmonary dysplasia (BPD), and retinopathy of prematurity (ROP).</p><p><b>RESULTS</b>Compared with the PCV group, the VTV group had a significantly shorter time of invasive ventilation (P<0.05) and significantly lower incidence rates of hypocapnia, VAP, and PVL (P<0.05); however, there were no significant differences in the duration of oxygen therapy, mortality, and incidence rates of pneumothorax, grade III-IV PVH-IVH, BPD, and ROP.</p><p><b>CONCLUSIONS</b>VTV has a better efficacy than PCV in the treatment of NRDS, and is worthy of clinical promotion and application.</p>