Up-regulation of Let-7a Expression Induces Gastric Carcinoma Cell Apoptosis In Vitro / 中国医学科学杂志(英文版)
Chinese Medical Sciences Journal
; (4): 44-47, 2017.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-281420
Biblioteca responsável:
WPRO
ABSTRACT
Objective To investigate effect of let-7a gene over-expression on apoptosis of gastric cancer cell lines SGC-7901.Methods The stable let-7a gene over-expressing SGC-7901 cells, SGC-7901/let-7a cells, were established using shRNA lentiviral vector methods. Real-time RT-PCR analysis was used to evaluate the expression level of let-7a mRNA. Cells apoptosis was assessed by flow cytometry.Results RT-PCR analysis revealed let-7a expression in SGC-7901/let-7a cells was significantly increased. Cellular apoptosis assay showed that over-expression of let-7a could increase apoptosis of SGC-7901 cells (P=0.002).Conclusion Up-regulating let-7a expression promoted apoptosis in SGC-7901 cells.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Neoplasias Gástricas
/
RNA Neoplásico
/
Regulação Neoplásica da Expressão Gênica
/
Regulação para Cima
/
Apoptose
/
MicroRNAs
/
Linhagem Celular Tumoral
/
Genética
/
Metabolismo
Limite:
Humanos
Idioma:
Inglês
Revista:
Chinese Medical Sciences Journal
Ano de publicação:
2017
Tipo de documento:
Artigo