Effect of modified Yupingfeng granule on nuclear factor-kappaB expression in mice with allergic contact dermatitis / 南方医科大学学报
Journal of Southern Medical University
; (12): 1582-1584, 2009.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-282645
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of modified Yupingfeng granule on nuclear factor-kappaB (NF-kappaB)expression in mice with allergic contact dermatitis (ACD).</p><p><b>METHODS</b>Mouse models of ACD were treated with the granules at low, medium and high doses, with normal saline and hydrocortisone as the negative and positive controls, respectively. The expressions of NF-kappaB and its distribution in the lesions were detected using immunohistochemistry.</p><p><b>RESULTS</b>The staining intensity, area and positive expression rates of NF-kappaB p50 were significantly different between the treatment group and the normal saline group (P<0.05).</p><p><b>CONCLUSION</b>Modified Yupingfeng granule can effectively inhibit the expression of NF-kappaB in ACD, which might be a possible mechanism for its therapeutic effect on ACD.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Medicamentos de Ervas Chinesas
/
Regulação da Expressão Gênica
/
NF-kappa B
/
Dermatite Alérgica de Contato
/
Usos Terapêuticos
/
Relação Dose-Resposta a Droga
/
Tratamento Farmacológico
/
Metabolismo
/
Camundongos Endogâmicos BALB C
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2009
Tipo de documento:
Artigo