Efficacy of hypofractionated radiotherapy combined with docetaxel for treatment of bone metastasis of lung cancer / 南方医科大学学报
Journal of Southern Medical University
; (12): 1442-1444, 2009.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-282675
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy of hypofractionated radiotherapy combined with docetaxel for treatment of bone metastasis of lung cancer and explore the factors related to the prognosis.</p><p><b>METHODS</b>Seventy-two patients with bone metastasis of lung cancer were divided into group A with hypofractionated radiotherapy at 3.0 Gy /fraction (once a day, 5 days per week for 30 Gy) and weekly docetaxel treatment at 60 mg for 2 weeks, and group B with radiotherapy alone at 2.0 Gy/fraction (once a day, 5 days per week for 40 Gy).</p><p><b>RESULTS</b>The total effective rate was 93.1% (67/72) in these patients, with a non-response rate of 6.9% (5/72). The total effective rate was 97.2% (35/36) in group A and 88.9% (32/36) in group B. After the radiotherapy, the analgesic effect showed no significant difference between the two groups, but the onset of the effect was faster in group B than in group A.</p><p><b>CONCLUSION</b>Local radiotherapy provides effective pain relief in patients with bone metastasis of lung cancer. High-dose fractionated irradiation can rapidly achieve the analgesic effect.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Prognóstico
/
Radioterapia
/
Neoplasias Ósseas
/
Resultado do Tratamento
/
Terapia Combinada
/
Fracionamento da Dose de Radiação
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Taxoides
/
Usos Terapêuticos
/
Tratamento Farmacológico
Tipo de estudo:
Estudo prognóstico
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2009
Tipo de documento:
Artigo