Expression of B7-H1 on peripheral blood mononuclear cells from chronic hepatitis B patients / 南方医科大学学报
Journal of Southern Medical University
; (12): 1635-1637, 2007.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-283069
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of B7-H1 on peripheral blood mononuclear cells from patients with chronic HBV infection.</p><p><b>METHODS</b>Immunofluorescent staining and flow cytometry assay were used to measure the expression of B7-H1 on peripheral blood CD3high T cells, CD19high B cells and CD14high monocytes from chronic HBV infected patients.</p><p><b>RESULTS</b>No significant difference was observed in B7-H1 expression on T cells and B cells between chronic HBV infected patients (CHB) and health controls (HC). B7-H1-expressing CD14high cells were significantly increased in chronic HBV-infected patients (19.17-/+11.64)% as compared with healthy controls [(7.30-/+5.49)%, P<0.01]. A significant positive correlation was found between B7-H1 expression on CD14high monocytes and serum ALT levels.</p><p><b>CONCLUSION</b>There is no significant difference in B7-H1 expression on T cells and B cells between CHB patients and healthy subjects. B7-H1, which is up-regulated on monocytes from chronic HBV-infected patients, in positively correlated to serum ALT levels, and may play a role in the persistence of HBV infection.</p>
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
/
ODS3 - Meta 3.3 Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
/
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
/
Hepatite
/
Doenças do Sistema Digestório
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Leucócitos Mononucleares
/
Linfócitos B
/
Monócitos
/
Linfócitos T
/
Antígenos CD
/
Estudos de Casos e Controles
/
Hepatite B Crônica
/
Alergia e Imunologia
/
Antígeno B7-H1
/
Metabolismo
Tipo de estudo:
Estudo observacional
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2007
Tipo de documento:
Artigo