Role of platelet-derived growth factor in the pathogenesis of preeclampsia / 南方医科大学学报
Journal of Southern Medical University
; (12): 1274-1276, 2007.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-283151
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the role of platelet-derived growth factor (PDGF) in the pathogenesis of preeclampsia (PRE).</p><p><b>METHODS</b>Thirteen normal and 20 PRE late-pregnancy women were enrolled in this study. The serum PDGF-BB levels were measured with enzyme-linked immunosorbent assay, and the expression of PDGF-B mRNA in the decidual blood vessel was determined using in situ hybridization.</p><p><b>RESULTS</b>PDGF-BB levels in PRE group was significantly higher than that in normal pregnant women (83.54 -/+34.52 vs 39.61-/+18.20, P<0.001), and the expression of PDGF-B mRNA in decidual blood vessel was also significantly higher in PRE group (P<0.001), showing a positive correlation between serum PDGF and PDGF-B mRNA expression (r=0.603, P<0.001).</p><p><b>CONCLUSION</b>PDGF is associated with the pathology of decidual blood vessel. Elevated serum PDGF levels and PDGF-B mRNA expression in the decidual blood vessel may play an important role in the pathogenesis of PRE.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Pré-Eclâmpsia
/
Sangue
/
Fator de Crescimento Derivado de Plaquetas
/
RNA Mensageiro
/
Regulação da Expressão Gênica
/
Proteínas Proto-Oncogênicas c-sis
/
Decídua
/
Genética
/
Metabolismo
Tipo de estudo:
Estudo de etiologia
Limite:
Adulto
/
Feminino
/
Humanos
/
Gravidez
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2007
Tipo de documento:
Artigo