Extraction, purification technology and antineoplastic effects of solamargine / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 2192-2195, 2011.
Article
em Zh
| WPRIM
| ID: wpr-283230
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To extract and purify of solamargine from Solanum nigrum, and to research its antineoplastic effects.</p><p><b>METHOD</b>S. nigrum was extracted refluently with 80% alcohol, solamargine was purified with silica gel column chromatography and recrystallization, and then conducted its structure identification and purity checks. Screened the effect on human tumor cell groth inhibition in vitro by MTT assay, and researched on the features in mice with H22 liver cancer or Ehrlich ascites tumor of solamargine.</p><p><b>RESULT</b>The concent of solamargine reached 97.9%. Solamargine had significantly inhibition on 6 tumor cells in vitro, and it had significantly inhibition on mice with H22 liver cancer or ehrlich ascites tumor in the 2.4 mg x kg(-1) dose of i.v.</p><p><b>CONCLUSION</b>Solamargine have the antineoplastic effect.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Farmacologia
/
Alcaloides de Solanáceas
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Linhagem Celular Tumoral
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Camundongos Endogâmicos ICR
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Antineoplásicos Fitogênicos
Limite:
Animals
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Female
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Humans
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2011
Tipo de documento:
Article