Comparison of antioxidative and antitumor activities of six flavonoids from Epimedium koreanum / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 715-718, 2007.
Article
em Zh
| WPRIM
| ID: wpr-283399
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the antioxidative and antitumor activities of flavonoids isolated from Epimedium koreanum.</p><p><b>METHOD</b>The compounds were separated by column chromatography with silica gel and Sephadex LH-20, and identified by spectral a- nalysis (ESI-MS, 1H-NMR and 13C-NMR) respectively. DPPH radical scavenging assay and MTT assay were used to observe the antioxidative and antitumor abilities.</p><p><b>RESULT</b>Six compounds were isolated from the the ethyl acetate extract of the aerial part. Their structures were identified as icariin (I), luteolin (II), baohuoside II (III), hyperoside (IV), epimedokoreanin B (V) and baohuoside I (VI). The results indicated that at concentrations of 3. 125-200 micromol x L(-1), compound I, III and VI had no ability to scavenge the DPPH radical, but the scavenging ability of compounds II, IV and V were stronger than that of Vit C in dose-dependant manner. Compounds I, II, V and VI could inhibit the proliferation of MCF-7 and HepG2 in dose-dependant manner, but compounds III and IV had no effect on the proliferation.</p><p><b>CONCLUSION</b>The antitumor activity of E. koreanum may be partially related to the antioxidantive activity of flavonoids.</p>
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Base de dados:
WPRIM
Assunto principal:
Patologia
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Farmacologia
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Plantas Medicinais
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Flavonoides
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Neoplasias da Mama
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Química
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Epimedium
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Linhagem Celular Tumoral
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Luteolina
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Proliferação de Células
Limite:
Female
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Humans
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2007
Tipo de documento:
Article