The impact of platelet membrane autoantibodies on high-dose dexamethasone therapy in patients with idiopathic thrombocytopenic purpura / 中华血液学杂志
Chinese Journal of Hematology
; (12): 619-621, 2009.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-283936
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the impact of platelet membrane glycoprotein (GP)-specific autoantibodies on high-dose dexamethasone therapy in patients with idiopathic thrombocytopenic purpura (ITP).</p><p><b>METHODS</b>Modified direct monoclonal antibody immobilization of platelet antigen assay (MAIPA) was used to detect platelet GPIIb/IIIa and/or GPI b specific autoantibodies. All patients received oral dexamethasone 40 mg/d for 4 days.</p><p><b>RESULTS</b>The response rate of high-dose dexamethasone in GPIIb/IIIa and/or GPIb specific autoantibody-negative patients was significantly different from that of antibody-positive patients (P<0.05). The response rate of GPIIb/IIIa specific autoantibody-positive patients was lower than that of antibody-negative patients (P<0.05). GPIb specific autoantibody had no significant impact on the efficacy of high-dose dexamethasone (P>0.05).</p><p><b>CONCLUSION</b>Platelet membrane GPIIb/IIIa-specific autoantibody can be a potential negative indicator for ITP patients'response to high-dose oral dexamethasone.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Autoanticorpos
/
Sangue
/
Dexametasona
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Resultado do Tratamento
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Púrpura Trombocitopênica Idiopática
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Complexo Glicoproteico GPIIb-IIIa de Plaquetas
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Complexo Glicoproteico GPIb-IX de Plaquetas
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Usos Terapêuticos
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Tratamento Farmacológico
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Alergia e Imunologia
Limite:
Adolescente
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Adulto
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Idoso
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Idoso, 80 anos ou mais
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Feminino
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Humanos
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Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Hematology
Ano de publicação:
2009
Tipo de documento:
Artigo