Microdeletions in the Y chromosome of patients with idiopathic azoospermia / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
; (6): 111-115, 2002.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-284062
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>AIM</b>To evaluate the occurrence and prevalence of microdeletions in the gamma chromosome of patients with azoospermia.</p><p><b>METHODS</b>DNA from 29 men with idiopathic azoospermia was screened by polymerase chain reaction (PCR) analysis with a set of gamma chromosome specific sequence-tagged sites (STSs) to determine microdeletions in the gamma chromosome.</p><p><b>RESULTS</b>Deletions in the DAZ (deleted in azoospermia) loci sgamma254 and sgamma255 were found in three patients with idiopathic azoospermia, resulting in an estimated frequency of deletions of 10.7% in idiopathic azoospermia men.</p><p><b>CONCLUSION</b>We conclude that PCR analysis is useful for the diagnosis of microdeletions in the Y chromosome, which is important when deciding the suitability of a patient for assisted reproductive technology such as testicular sperm extracion-intracytoplasmic sperm injection (TESE-ICSI).</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oligospermia
/
Prolactina
/
Testosterona
/
Sangue
/
Hormônio Luteinizante
/
Sequência de Bases
/
Heterocromatina
/
Reação em Cadeia da Polimerase
/
Sitios de Sequências Rotuladas
/
Deleção de Sequência
Limite:
Adulto
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Asian Journal of Andrology
Ano de publicação:
2002
Tipo de documento:
Artigo