Optimization of dry granulating technique of Qibai Pingfei granule through response surface methodology / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 2975-2978, 2015.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-284815
Biblioteca responsável:
WPRO
ABSTRACT
To determine the optimum process conditions for dry granulating technique of Qibai Pingfei granule, granule excipient type, rolling wheel speed and pressure and feeding speed were studied. Taking shaping rate at a time, moisture absorption and dissolubility as index, the type and amount of granule excipient were determined. In addition, taking shaping rate at a time as index, parameters of rolling wheel speed and pressure and feeding speed were researched through single factor test and response surface methodology. The optimum parameters were as follows lactose as excipient, dry extract powder to excipient at 12, rolling wheel speed and pressure at 10.9 Hz and 6.4 MPa and feeding speed at 7.2 Hz. After validation of three batches pilot-scale production, the optimum processing parameters for dry granulating technique of Qibai Pingfei granule is reasonable and feasible, which can provide reliable basis for production.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pós
/
Medicamentos de Ervas Chinesas
/
Tecnologia Farmacêutica
/
Métodos
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2015
Tipo de documento:
Artigo