Antioxidant activities of crude phlorotannins from Sargassum hemiphyllum / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences)
; (6): 449-455, 2016.
Article
em En
| WPRIM
| ID: wpr-285247
Biblioteca responsável:
WPRO
ABSTRACT
Brown algae are well known as a source of biologically active compounds, especially those having antioxidant activities, such as phlorotannins. In this study we examined the antioxidant activities of crude phlorotannins extracts (CPEs) obtained from Sargassum hemiphyllum (SH) and fractionated according to the molecular weights. When CPEs were administrated at a dose of 30 mg/kg to Kunming mice pre-treated with carbon tetrachloride (CCl4), the levels of oxidative stress indicators in the liver, kidney and brain were significantly reduced in vivo. All the components of various molecular weight fractions of CPEs exhibited greater scavenging capacities in clearing hydroxyl free radical and superoxide anion than the positive controls gallic acid, vitamin C and vitamin E. Particularly, the components greater than 30 kD obtained from ethyl acetate phase showed the highest antioxidant capacities. These results indicated that SH is a potential source for extracting phlorotannins, the algal antioxidant compounds.
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Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Oxirredução
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Patologia
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Farmacologia
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Ácido Ascórbico
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Taninos
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Vitamina E
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Encéfalo
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Tetracloreto de Carbono
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Intoxicação por Tetracloreto de Carbono
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Química
Limite:
Animals
Idioma:
En
Revista:
Journal of Huazhong University of Science and Technology (Medical Sciences)
Ano de publicação:
2016
Tipo de documento:
Article