Effect of preoperative transcatheter arterial chemoembolization on the perioperative outcome of patients with hepatocellular carcinoma / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 671-675, 2015.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-286743
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the surgical risk, perioperative outcome and the response of patients with hepatocellular carcinoma (HCC) after preoperative transcatheter arterial chemoembolization (TACE).</p><p><b>METHODS</b>A retrospective case-matched study was conducted to compare the characteristics and corresponding measures of patients in the preoperative TACE group and the control group without TACE. A total of 105 patients (82 patients with selective and dynamic region-specific vascular occlusion to perform hepatectomy for patients with complex hepatocellular carcinoma) was included in this study, in which 35 patients underwent TACE therapy, and a 12 matched control group of 70 subjects.</p><p><b>RESULTS</b>The patients of preoperative TACE therapy group had a higher level of γ-glutamyl transpeptidase before operation (119.52±98.83) U/L vs. (67.39±61.25) U/L (P=0.040). The operation time was longer in the TACE group than that in the control group but with a non-significant difference (232.60±95.43) min vs. (218.70±75.13) min (P=0.052). The postoperative recovery of liver function and severe complications in the preoperative TACE group were similar to that in the control group (P>0.05). There were no massive hemorrhage, biliary fistula and 30-d death neither in the treatment group and matched control group.</p><p><b>CONCLUSIONS</b>Preoperative TACE therapy has certain negative effect on liver function. It is preferable to use selective and dynamic region-specific vascular occlusion technique during hepatectomy and combine with reasonable perioperative treatment for this group of patients, that can ensure safety of patients and promote their rapid recovery.</p>
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Doenças do Sistema Digestório
/
Neoplasia Hepática
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Terapêutica
/
Estudos de Casos e Controles
/
Estudos Retrospectivos
/
Quimioembolização Terapêutica
/
Carcinoma Hepatocelular
/
Recuperação de Função Fisiológica
/
Período Pré-Operatório
/
Duração da Cirurgia
/
Gama-Glutamiltransferase
/
Hepatectomia
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Oncology
Ano de publicação:
2015
Tipo de documento:
Artigo