Expression and clinical significance of CIP2A in small cell lung cancer patients / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 517-520, 2015.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-286788
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the expression of cancerous inhibitor of phosphatase 2A (CIP2A) protein in small cell lung cancer and their relationship with clinicpathological features and prognosis.</p><p><b>METHODS</b>A total of 112 cases of surgical specimens or bronchoscopic biopsies of small cell lung cancer were collected. There were specimens of 94 cases of SCLC tissues and 40 cases of paracancerous lung tissues. Quantitative RT-PCR and immunohistochemistry analysis were performed to determine the CIP2A expression in SCLC tissues. Kaplan-Meier curves were used to estimate the association between CIP2A expression and clinicopathological characteristics and prognosis of the patients.</p><p><b>RESULTS</b>The expression of CIP2A in SCLC tissue was 7.605 ± 1.893, significantly higher than that in the paracancerous tissues (1.041 ± 0.786) (P < 0.01). The positive rate of CIP2A expression in cancer tissues was 82.8%, significantly higher than that in the paracancerous tissues (13.3%) (P < 0.01). The median disease-free survival was 9.88 months in the CIP2A-high expressing patients, significantly shorter than the 20.92 months in CIP2A-low expressing patients (P < 0.001). CIP2A expression was significantly correlated with the tumor stage, chemotherapeutic sensitivity, and survival (P < 0.05 for all).</p><p><b>CONCLUSIONS</b>CIP2A expression is associated with the pathogenesis of SCLC, and may become a potential prognostic indicator of SCLC.</p>
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Disponível
Contexto em Saúde:
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Outras Doenças Respiratórias
/
Neoplasias do Pulmão, Traqueia e Brônquios
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Autoantígenos
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Imuno-Histoquímica
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Biomarcadores Tumorais
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Mortalidade
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Intervalo Livre de Doença
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Reação em Cadeia da Polimerase Via Transcriptase Reversa
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Estimativa de Kaplan-Meier
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Carcinoma de Pequenas Células do Pulmão
/
Pulmão
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Oncology
Ano de publicação:
2015
Tipo de documento:
Artigo