Ambroxol for the prevention of respiratory distress syndrome in preterm infants: a meta analysis / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 858-863, 2010.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-286964
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy and safety of ambroxol in the prevention of respiratory distress syndrome (RDS) in preterm infants.</p><p><b>METHODS</b>Electronic searches were performed in the Cochrane Library, PubMED, EMBASE, Chinese CBM, Chinese VIP Database, Chinese Wanfang Database and Chinese CNKI Database up to the year of 2009 for randomized controlled trials (RCT) on ambroxol for the prevention of RDS in preterm infants. The meeting articles related to the RCT were manually searched in Pediatrics and Pediatric Research. Meta analysis was performed for the results of homogeneous studies by the Cochrane Collaboration's software RevMan 5.0.17.</p><p><b>RESULTS</b>Six RCTs involving 823 preterm infants were included, and the quality assessment for the trials demonstrated 1 article as A class, 1 article as B class and 4 articles as C class. The Meta analysis showed that ambroxol administration significantly reduced the incidence of RDS (OR=0.24, 95%CI 0.15 - 0.64, P<0.01), bronchopulmonary dysplasis (BPD, OR=0.41, 95%CI 0.23 - 0.75, P<0.01), intraventricular hemorrhage (IVH, OR=0.39, 95%CI0.24 - 0.64, P<0.01), patent ductus arteriosus (PDA, OR=0.33, 95%CI 0.17 - 0.67, P<0.01) and pulmonary infection (OR=0.24, 95%CI0.14 - 0.38, P<0.01). No adverse events related to the ambroxol treatment were reported.</p><p><b>CONCLUSIONS</b>The current evidence shows that early use of ambroxol can reduce the risk of RDS, BPD, IVH, PDA and pulmonary infection in preterm infants.</p>
Texto completo:
Disponível
Contexto em Saúde:
Agenda de Saúde Sustentável para as Américas
Problema de saúde:
Objetivo 9: Redução de doenças não transmissíveis
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Síndrome do Desconforto Respiratório do Recém-Nascido
/
Displasia Broncopulmonar
/
Recém-Nascido Prematuro
/
Ensaios Clínicos Controlados Aleatórios como Assunto
/
Hemorragia Cerebral
/
Usos Terapêuticos
/
Permeabilidade do Canal Arterial
/
Ambroxol
Tipo de estudo:
Ensaio clínico controlado
/
Revisão sistemática
Limite:
Humanos
/
Recém-Nascido
Idioma:
Chinês
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2010
Tipo de documento:
Artigo