The investigation of the relationship between the phenotypes of 46, XX males and the SRY gene / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 95-97, 2009.
Article
em Zh
| WPRIM
| ID: wpr-287445
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between the phenotypes in XX male patients and the sex determining region(SRY) gene.</p><p><b>METHODS</b>Multiple polymerase chain reactions were carried out in 6 male patients with karyotype of 46, XX, and then the PCR products were sequenced directly.</p><p><b>RESULTS</b>Three cases of male infertility were positive for the SRY gene without evident malformation in their extra genitalia, while 3 cases with testes were negative for the SRY gene, with evident malformation in their extra genitalia.</p><p><b>CONCLUSION</b>The SRY gene is key in sex determination and development, yet there might be other important genes involved.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Patologia
/
Fenótipo
/
Aberrações dos Cromossomos Sexuais
/
Reação em Cadeia da Polimerase
/
Análise de Sequência de DNA
/
Transtornos dos Cromossomos Sexuais
/
Genes sry
/
Genética
/
Genitália Masculina
Limite:
Adult
/
Child, preschool
/
Humans
/
Infant
/
Male
Idioma:
Zh
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2009
Tipo de documento:
Article