Effect of Rhizoma coptidis and Radix rehmanniae with different ratio on pharmacokinetics of berberine in rats / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1795-1797, 2007.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-287890
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of Rhizoma Coptidis and Radix Rehmanniae with the different ratio on the pharmacokinetics of berberine in rats.</p><p><b>METHOD</b>24 rats were grouped to 4 groups randomly. Decoction, in which the proportion of Rhizoma Coptidis to Radix Rehmanniae is 10, 11, 14, 18 differently, was intragastrically given to the 4 groups. HPLC was used to determine concentration of berberine in serum. We adopted DAS 2.0 to analysis pharmacokinetic parameters of berberine.</p><p><b>RESULT</b>The concentration-time curves was all fitted to two-compartment model with a weight of 1/C2. Difference of 4groups in C(max), AUC(0-t), AUC(0-infinity), is significant (P <0.05).</p><p><b>CONCLUSION</b>Radix Rehmanniae of large dose can effectively enhance berberine's bioavailability in rats.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plantas Medicinais
/
Berberina
/
Sangue
/
Medicamentos de Ervas Chinesas
/
Farmacocinética
/
Disponibilidade Biológica
/
Distribuição Aleatória
/
Química
/
Ratos Sprague-Dawley
/
Raízes de Plantas
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2007
Tipo de documento:
Artigo