Clinical significance of detecting t(11;14) by fluorescence in situ hybridization for the diagnosis of 7 patients with atypical mantle cell lymphoma / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 13-16, 2016.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-287960
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the clinical features and diagnosis of 7 patients with atypical mantle cell lymphoma (MCL).</p><p><b>METHODS</b>The 7 MCL patients were misdiagnosed as chronic lymphocytic leukemia (CLL) due to a score of 4 for their immunophenotypes. The clinical features and diagnosis of such patients were retrospectively analyzed.</p><p><b>RESULTS</b>Six patients had superficial lymphadenectasis but their lymph nodes could not be palpated. All 7 patients were as stage IV considering bone marrow infiltration. Scores of immunophenotype of CLL were 4, and interphase fluorescence in situ hybridization (FISH) for t(11;14) were positive in all patients.</p><p><b>CONCLUSION</b>Some MCL patients have clinical features similar to CLL. Interphase FISH can play an important role in the diagnosis of MCL.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Translocação Genética
/
Cromossomos Humanos Par 11
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Cromossomos Humanos Par 14
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Hibridização in Situ Fluorescente
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Linfoma de Célula do Manto
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Diagnóstico
/
Genética
/
Métodos
Tipo de estudo:
Estudo diagnóstico
Limite:
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2016
Tipo de documento:
Artigo