Second-Line Chemotherapy in Advanced Biliary Tract Cancer: A Retrospective Analysis
Soonchunhyang Medical Science
; : 75-81, 2015.
Article
em En
| WPRIM
| ID: wpr-28819
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE: The evidence of 2nd line chemotherapy has not been validated. We investigated the treatment outcomes of 2nd line palliative chemotherapy in patients with biliary tract cancer (BTC) and analyzed the factors affecting response or survival. METHODS: We retrospectively reviewed and analyzed the outcomes in advanced BTC patients who underwent 2nd line chemotherapy in Soonchunhyang Universitiy Hospitals (Bucheon, Seoul, and Cheonan). RESULTS: From December 2004 to May 2014, 65 patients were enrolled. The median age was 56 years (range, 40 to 76 years) and the ratio of cholangiocarcinoma (intrahepatic or extrahepatic), gall bladder cancer, and ampulla of Vater cancer was 41 (63.1%):18 (27.7%):6 (9.25%). Half of the patients (33 patients, 50.8%) were treated with gemcitabine-based and 28 patients (43.1%) with 5-fluorouracil- based therapy. The response rate was 3.0% and disease control rate was 21.5% in intention-to-treat analysis. Median overall survival (OS) was 7.2 months (95% confidence interval [CI], 3.9 to 10.5 months) and median progression free survival (PFS) was 3.7 months (95% CI, 2.5 to 4.9 months). In multivariate analysis, patients with good performance status (PS) (P=0.001) and chemo-sensitive tumor to 2nd line chemotherapy (P=0.000) had longer PFS as compared to the others. In addition, patients with good PS (P=0.003), chemo-sensitive tumor to 1st line (P=0.046), and 2nd line chemotherapy (P=0.004) were good prognostic factors for OS. CONCLUSION: The effect of 2nd line chemotherapy in advanced BTC was modest and maybe beneficial in select patients.
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Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Ampola Hepatopancreática
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Sistema Biliar
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Neoplasias do Sistema Biliar
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Análise Multivariada
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Estudos Retrospectivos
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Terapia de Salvação
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Colangiocarcinoma
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Intervalo Livre de Doença
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Tratamento Farmacológico
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Seul
Tipo de estudo:
Observational_studies
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Prognostic_studies
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Soonchunhyang Medical Science
Ano de publicação:
2015
Tipo de documento:
Article