Effect on xenograft of nude mouse by combination therapy of nm23-H1 and protein-cisplatin / 华西口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the effect of protein-cisplatin and nm23-H1 therapy on the tumor of nude mouse.</p><p><b>METHODS</b>The 15 BALB/C female mice were divided into three groups, control group, protein-cisplatin group and protein-cisplatin+nm23-H1 plasmid group. Tca8113 were injected into the mice subcutaneously with the concentration of 3.1 x 10(6) cells/mL. After two weeks, the mixture of lipofectin and nm23-H1 was injected around xenograft of nude mouse. After three days, the protein-cisplatin was injected around xenograft. The weight of mouse, the volume and the weight of xenograft were measured.</p><p><b>RESULTS</b>The weight of mouse was lightest in control group. The volume and weight of the transplanted tumor were lightest in nm23-H1 +protein-cisplatin group.</p><p><b>CONCLUSION</b>The combination therapy of nm23-H1 and protein-cisplatin can effectively inhibites the growth of xenograft in nude mouse.</p>