Effect of different nutritional routes on the intestinal mucus barrier in scalded rats / 中华烧伤杂志
Chinese Journal of Burns
; (6): 339-342, 2002.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-289161
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effect of different nutritional routes of giving nutrition on the intestinal mucus barrier in severely scalded rats.</p><p><b>METHODS</b>Wistar rats inflicted with 30% TBSA III degree scalding on the back were employed as the model and were randomly divided into 3 groups, i.e. control (C), parenteral nutrition (PN) and enteral nutrition (EN) groups. The rats in PN and EN groups were supplied with equal amount of nitrogen and calories and with equal volume of nutrition solution. The dynamic changes in the thickness of intestinal mucus layer and the contents of protein, hexose and acetylneuraminate in the mucus were examined.</p><p><b>RESULTS</b>When compared with those in C group, the intestinal mucus layer became thinner and the contents of protein, hexose and acetylneuraminate in the mucus in both PN and EN groups decreased evidently after scalding. When compared between two nutritional groups, the thickness of intestinal mucus layer and the contents of the hexose and acetylneuraminate in the mucus in EN were much thicker and higher than those in PN group, while the mucus protein content exhibited no obvious difference between PN and EN groups.</p><p><b>CONCLUSION</b>It was suggested that intestinal goblet cell synthesized and secreted less mucus after scalding in rats resulting in thinning of intestinal mucus layer and the change in mucus components. When compared with those in PN group, less injury to the intestinal goblet cells occurred and the intestinal mucus synthesis was less affected in EN group, and the components of intestinal mucus were maintained stable.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Ácidos Siálicos
/
Fatores de Tempo
/
Queimaduras
/
Proteínas
/
Nutrição Enteral
/
Nutrição Parenteral
/
Ratos Wistar
/
Hexoses
/
Mucosa Intestinal
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Burns
Ano de publicação:
2002
Tipo de documento:
Artigo