Preparation and in vitro release characteristics of curcumin in nanosuspensions / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To prepare curcumin albumin nanosuspensions and study its release characteristics in vitro.</p><p><b>METHOD</b>Curcumin albumin nanosuspensions were prepared by solvent evaporation method. The nanosuspensions were characterized in terms of morphology, size, encapsulation efficiency and in vitro drug release.</p><p><b>RESULT</b>The mean size of albumin nanosuspensions before lyophilization was 245.2 nm and 240.3 nm after reconstitution. The distribution of particle size was uniform. The encapsulation efficiency was (42.39 +/- 0.91)%. In vitro release study revealed that the 72 h accumulative release percentage reached 96%.</p><p><b>CONCLUSION</b>The method described to prepare curcumin albumin nanosuspensions is simple. It might be a novel vehicle potentially for nanoparticle drug delivery system of curcumin.</p>