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Study on transmission rate and quantitative structure-property relationships of alkaloids and iridoid compounds on UF membranes with MWCOS of 1000 / 中国中药杂志
Article em Zh | WPRIM | ID: wpr-289415
Biblioteca responsável: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>Taking alkaloids and iridoid as the study, relationships of quantitative molecular structure and transmission rate on UF membrane were developed initially at exploring the mechanism of UF in Chinese herb decoction and to lay a foundation for the optimal design of membrane technology in the production of Chinese drugs preparation.</p><p><b>METHOD</b>The transmission rate of eight alkaloids and iridoid compounds in three UF membranes was determined, and quantitative structure-property relationships between quantitative molecular structure and transmission rate were developed by the data mining method of PLS or SVM.</p><p><b>RESULT</b>Quantitative structure-property relationship models of three membranes were developed by the data mining method of PLS or SVM, correlation coefficients were all greater than 0.9. The parameters in the models included LUMO, AlogP, CMR, K&H2, K&H3.</p><p><b>CONCLUSION</b>The relationship of UF transmission rate of these eight compounds and their molecular weight are not simply linearly dependent, the main factors which affect the UF transmission rate are capacity of gain or loss electron, hydrophilicity or hydrophobic and compound spatial structure.</p>
Assuntos
Texto completo: 1 Base de dados: WPRIM Assunto principal: Permeabilidade / Farmacologia / Medicamentos de Ervas Chinesas / Preparações Farmacêuticas / Ultrafiltração / Química / Relação Quantitativa Estrutura-Atividade / Iridoides / Alcaloides / Métodos Tipo de estudo: Prognostic_studies Idioma: Zh Revista: China Journal of Chinese Materia Medica Ano de publicação: 2011 Tipo de documento: Article
Texto completo: 1 Base de dados: WPRIM Assunto principal: Permeabilidade / Farmacologia / Medicamentos de Ervas Chinesas / Preparações Farmacêuticas / Ultrafiltração / Química / Relação Quantitativa Estrutura-Atividade / Iridoides / Alcaloides / Métodos Tipo de estudo: Prognostic_studies Idioma: Zh Revista: China Journal of Chinese Materia Medica Ano de publicação: 2011 Tipo de documento: Article