Expression of the p16(INK4a) and Ki-67 in relation to the grade of cervical intraepithelial neoplasia and high-risk human papillomavirus infection / 부인종양
Journal of Gynecologic Oncology
; : 162-168, 2008.
Article
em En
| WPRIM
| ID: wpr-28970
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE: The purposes of this study were to evaluate the expression of p16(INK4a) (referred as to p16) and Ki-67 in cervical intraepithelial neoplasia (CIN), and the correlation between high-risk human papillomavirus (HPV) infection and the above biomarkers. METHODS: We analyzed 31 patients who were diagnosed with CIN at Kwandong University Myongji Hospital from October 2006 to September 2007. CIN specimens (CIN1, 12; CIN2, 6; CIN3, 13) were obtained by colposcopy-directed biopsy (CDB) or loop electrical excision procedure (LEEP). The expressions of p16 and Ki-67 were evaluated by immunohistochemical methods with antibodies to p16 and Ki67. The immunohistochemical staining results were classified into four grades: 0, 1, 2 and 3. HPV genotyping or Hybrid Capture-II test was used to detect high-risk HPV. RESULTS: The expression of p16 (p<0.001) and Ki-67 (p=0.003) were positively associated with CIN grade. p16 expressions increased significantly with high-risk HPV infection (p=0.014), especially HPV type 16 and 58. Ki-67 expression was not related with high-risk HPV. There was positive correlation between the expression of the p16 and Ki-67 (p=0.007). CONCLUSION: CIN grade were positively related to the expression of p16 and Ki-67. p16 expressions of high-risk HPV specimens significantly increased more than Ki-67. Therefore, in the diagnosis of CIN and high-risk HPV infection, p16 can be a useful biomarker.
Palavras-chave
Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Biópsia
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Biomarcadores
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Displasia do Colo do Útero
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Quimera
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Inibidor p16 de Quinase Dependente de Ciclina
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Infecções por Papillomavirus
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Papillomavirus Humano 16
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Anticorpos
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
Journal of Gynecologic Oncology
Ano de publicação:
2008
Tipo de documento:
Article