Successful preimplantation genetic diagnosis of Hb Bart's hydrops fetalis in Singapore after fresh and frozen embryo replacement cycles
Annals of the Academy of Medicine, Singapore
; : 910-913, 2009.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-290289
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>INTRODUCTION</b>We report the fi rst successful preimplantation genetic diagnosis (PGD) for Hb Bart's hydrops fetalis in Singapore, involving both fresh and frozen embryo replacement cycles.</p><p><b>CLINICAL PICTURE</b>Two couples who were carriers of the Southeast Asian type double gene deletion (--(SEA) deletion carriers) requested for PGD. Couple A had 2 previous affected pregnancies, while couple B have a child of unknown genotypic status.</p><p><b>TREATMENT</b>One PGD cycle was performed for each couple. The --(SEA) deletion was detected using a gap-PCR strategy. Couple A had 1 fresh-embryo replacement cycle while couple B underwent 2 frozen-embryo replacement cycles.</p><p><b>OUTCOME</b>Couple A achieved a twin pregnancy. Second trimester complications resulted in premature delivery, where 1 baby girl survived. Couple B achieved a singleton pregnancy resulting in delivery of a healthy baby boy. Genotype analysis of all babies confirmed the PGD results consistent with clinically unaffected status.</p><p><b>CONCLUSIONS</b>We have successfully performed PGD to avoid Hb Bart's hydrops fetalis syndrome.</p>
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
Problema de saúde:
Meta 3.2: Reduzir as mortes de recém nascidos e crianças com menos de 5 anos
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Indução da Ovulação
/
Complicações Hematológicas na Gravidez
/
Singapura
/
Hemoglobinas Anormais
/
Hidropisia Fetal
/
Testes Genéticos
/
Reação em Cadeia da Polimerase
/
Repetições Minissatélites
/
Diagnóstico Pré-Implantação
/
Injeções de Esperma Intracitoplásmicas
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
/
Gravidez
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Annals of the Academy of Medicine, Singapore
Ano de publicação:
2009
Tipo de documento:
Artigo