Report of 8 cases of bcr-abl gene positive thrombocytosis and review of the literature / 中华血液学杂志
Chinese Journal of Hematology
; (12): 528-531, 2004.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-291386
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To analyse the features of 8 cases of Bcr(+) thrombocytosis.</p><p><b>METHODS</b>The clinical and hematological features and therapeutic outcomes were studied retrospectively in 8 Bcr(+) thrombocytosis and compared with essential thrombocytosis (ET) and chronic myeloid leukemia-chronic phase thrombocytosis (CML-CP-T). BCR-ABL fusion gene was detected with PCR.</p><p><b>RESULTS</b>(1) Except for the presence of BCR-ABL fusion gene, there was no significant difference in clinical and hematological features and therapeutic outcomes between thrombocytosis with or without BCR-ABL. (2) The Bcr(+) thrombocytosis differed from CML-CP-T in the following aspects female predominance, milder or no splenomegaly, peripheral leukocytes count < 40 x 10(9)/L, less or no basophilia and fewer immature granulocytes in peripheral blood, bone marrow granulocytic and/or megakaryocytic lineage hyperplasia, normal or increased neutrophil alkaline phosphatase score and less blastic transformation.</p><p><b>CONCLUSION</b>Bcr(+) thrombocytosis may be considered as a new member of chronic myeloproliferative diseases, a variant of essential thrombocythemia.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Prognóstico
/
Terapêutica
/
Trombocitose
/
Leucemia Mieloide de Fase Crônica
/
Proteínas de Fusão bcr-abl
/
Genética
Tipo de estudo:
Estudo prognóstico
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Hematology
Ano de publicação:
2004
Tipo de documento:
Artigo