Gene expression profile in early differentiation of K562 cells induced by matrine / 中华血液学杂志
Chinese Journal of Hematology
; (12): 342-345, 2004.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-291416
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To compare gene expression profile in K562 cells induced by matrine, so as to screen for differentiation related genes.</p><p><b>METHODS</b>K562 cells were exposed to 0.1 mg/ml matrine for 3 hours, and gene expression profiles in matrine-treated and non-treated cells were studied by cDNA microarray.</p><p><b>RESULTS</b>From 8465 screened genes, 30 differentially expressed genes were found. Among them 18 showed decreased expression including oncogene and proto-oncogene, signal transduction gene, DNA binding and transcription gene etc, 12 showed increased expression including cell receptor gene, immune-associated gene, metabolism-associated gene etc in matrine-treated K562 cells as compared with that in non-treated cell.</p><p><b>CONCLUSION</b>The genes, that are closely associated with differentiation of can-cer cell, could be the potential targets for cancer treatment.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Quinolizinas
/
Regulação Neoplásica da Expressão Gênica
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Diferenciação Celular
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Células K562
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Análise de Sequência com Séries de Oligonucleotídeos
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Perfilação da Expressão Gênica
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Biologia Celular
/
Alcaloides
/
Genética
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Hematology
Ano de publicação:
2004
Tipo de documento:
Artigo